Why 3D human models will increasingly replace mice in drug testing & How do we make human 3D models not only more relevant — but also reproducible enough for decisions ?
How do we make human 3D models not only more relevant — but also reproducible enough for decisions?
1) Why 3D human models will increasingly replace mice in drug testing
How do we make human 3D models not only more relevant — but also reproducible enough for decisions?
Animal models are still valuable — but they can mis-predict human outcomes, leading to false positives (effective in animals, fails in humans) and false negatives (discarded due to animal-only findings).
Source: Hartung, T. (2024), Frontiers in Drug Discovery
That’s why the industry is shifting toward human-relevant 3D tissue models that better reflect human microenvironments, improving confidence earlier in the pipeline.
Example context (3D spheroids/organoids)
2) How Poietis Biosystems contributes to this change
Where Poietis’ NGB creates real value (benefits, not buzzwords):
- Stronger decision-making earlier: complex 3D models designed to better capture human biology than simplified systems
- More consistent screening: focus on reproducible, automated fabrication of structured 3D models (critical for comparability across runs/teams)
- Faster iteration cycles: accelerate model development from design to structured tissues to support R&D pace
- Aligned with advanced workflows: highlighted use cases in organ-on-chip, disease modeling and drug discovery
→ Our post about “Revolutionizing Organ-on-Chip Models with Next-Generation Bioprinting”
3) Regulatory and ethical matters
Europe is moving too: the European Commission is working on a roadmap to phase out animal testing for chemical safety assessment – (EC Roadmap)
In the US, the FDA is also encouraging the use of NAMs (e.g., organoids, organ-on-chip, in silico models) to reduce animal testing in parts of preclinical safety – (FDA announcements)
WHAT’S YOUR BIGGEST CHALLENGE WITH 3D MODELS ?
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Projected use on NGB
The same laser-assisted process runs on the NGB-R® research platform and continues on the GMP-grade NGB-C® for clinical translation. Map this to your own model →
