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Laser-Assisted Bioprinting

The laser advantage

The NGB platform is modular: laser and bioextrusion print living cells, hydrogels, and cell spheroids with high precision. Laser-Assisted Bioprinting, patented and validated on 40+ cell types, sets the benchmark for reproducibility, precision, and viability.

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40+

Cell types validated on the laser bioprinting technology

95%

Cell viability with nozzle-free deposition

~pL

Droplet volume, single cell to a few cells

How Laser-Assisted Bioprinting works

Create complex cell patterns with Laser-Assisted Bioprinting. It is based on laser-induced forward transfer: no nozzle, no mechanical contact with the cells.

Step 1

Pulse

A focused laser pulse hits a cartridge holding a thin film of bio-ink.

Step 2

Jet

The pulse forms a jet that releases a picoliter droplet toward the substrate.

Step 3

Scan

Rapid cartridge scanning deposits up to 10,000 droplets per second, with no shear stress.

From file to tissue, in six steps

A guided, reproducible workflow - the same result on every run, in any pair of hands.

Design

Define your construct layer by layer, with cell-level positioning, in the bioprinting software.

Prepare

Load your bioinks, cells, hydrogels, and spheroids into the platform's cartridges and ribbons.

Calibrate

Automated calibration and cell detection set the system for accurate, repeatable deposition.

Laser and bioextrusion deposit material with micrometric precision and no nozzle contact.

Monitor

Built-in visualization gives real-time, in-process control of the print as it builds.

Mature

Move to culture and maturation, toward a functional, structured tissue construct.

Three advantages, by design

Resolution

Unrivaled resolution

Tune resolution through cell concentration and laser energy for ultra-precise 3D cellular constructs.

Polyvalence

High polyvalence

Print diverse bio-inks, cell types, and materials, with the exclusive ability to print cell aggregates.

Viability

Exceptional cell viability

The nozzle-free approach preserves cells, with viability up to 95%.

Laser, inkjet, or extrusion

Alternatives can look cheaper to buy. For accuracy, viability, and the cost of use at scale, laser changes the equation.

Poietis

Laser

Droplets, picoliter to nanoliter
Single-cell precision, cell aggregates
Nozzle-free, no shear stress
Viability up to 95%

Inkjet

Droplets through a nozzle
Risk of clogging and shear
Limited with high cell densities
Lower upfront cost

Extrusion

Filaments up to 100 µm
Viscous, gel-type biomaterials
Good for structural scaffolds
Mechanical shear on cells

The NGB platform combines laser and bioextrusion, so you are not forced to choose.

Robotized & multimodal

One platform, laser and bioextrusion

A completely robotized and automated laser bioprinting system, with a microfluidic cartridge, peristaltic pumps, and a 6-axis robotic arm enabling multicolor printing of up to three different cell types.

Combined with bioextrusion in the NGB platform, it covers research and clinical applications in one patented system.

See the NGB-R® system →

What you can achieve

Faithfully reproduce the 3D architecture, biochemical gradients, and multicellular interactions that govern tissue function in vivo, across oncology, drug testing, and regenerative medicine.

Oncology

3D tumour microenvironment models

Structured TME models integrating tumour, stroma, immune compartments, and ECM mechanics. A more realistic test bed for immuno-oncology agents, biologics, and drug-resistance studies than conventional multicellular spheroids.

Regenerative medicine

Poieskin®, the first therapeutic bioprinted tissue

Autologous full-thickness skin substitute, 40 cm2, manufactured on NGB-C® under GMP-compatible conditions. Phase I/IIa trial (BIOPSKIN) in progress at AP-HM, Marseille.

Building blocks

Stem cellsCellsOrganoidsHydrogels

Biofabrication strategies

3D modelsOrgan-on-chipTissue constructsSingle cell

Tissues & organs

SkinCorneaLiverLungHeartCartilageNeural tissueComplex tissue

Disease modeling

OncologyRare diseasesNeuro-metabolismTraumatic surgery

Markets

BiopharmaDrug screeningBasic researchRegenerative medicineCosmetics

Two systems, one continuum

For research

NGB-R®

Oncology, tissue and disease models, with single-cell precision.

Discover NGB-R® →

For GMP manufacturing

NGB-C®

Clinical-grade, GMP-compliant, for therapeutic applications and regenerative medicine.